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Article

Phenotypic insights into genetic risk factors for immune-related adverse events in cancer immunotherapy.

Cancer immunology, immunotherapy : CII - 2 Nov 2024

Ma Haochuan, Song Dili, Zhang Haibo, Li Taidong, Jin Xing

Abstract excerpt

BACKGROUND: Immune-related adverse events (irAEs) pose substantial challenges in the realm of cancer immunotherapy, frequently affecting treatment efficacy and patient safety. To address the urgent need for identifying risk factors associated with irAEs, we conducted a comprehensive phenotype-wide Mendelian randomization analysis (MR-PheWAS). METHODS: Utilizing publicly accessible genome-wide association study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39487892
DOI: 10.1007/s00262-024-03854-8
PMCID: PMC11531409

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