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Article

Whole Genome Sequencing Revealed Inherited Rare Oligogenic Variants Contributing to Schizophrenia and Major Depressive Disorder in Two Families.

International journal of molecular sciences - 21 Jul 2023

Chung I-Hang, Huang Yu-Shu, Fang Ting-Hsuan, Chen Chia-Hsiang

Abstract excerpt

Schizophrenia and affective disorder are two major complex mental disorders with high heritability. Evidence shows that rare variants with significant clinical impacts contribute to the genetic liability of these two disorders. Also, rare variants associated with schizophrenia and affective disorders are highly personalized; each patient may carry different variants. We used whole genome sequencing analysis to...

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PMID: 37511534
DOI: 10.3390/ijms241411777
PMCID: PMC10380944

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