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Article

Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness.

Molecular psychiatry - 1 Dec 2016

Homann O R, Misura K, Lamas E, Sandrock R W, Nelson P, McDonough S I, DeLisi L E

Abstract excerpt

A current focus in psychiatric genetics is detection of multiple common risk alleles through very large genome-wide association study analyses. Yet families do exist, albeit rare, that have multiple affected members who are presumed to have a similar inherited cause to their illnesses. We hypothesized that within some of these families there may be rare highly penetrant mutations that segregate with illness. In...

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Identifiers

PMID: 27001614
DOI: 10.1038/mp.2016.24
PMCID: PMC5033653

Genes

SMARCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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