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Article

Common and rare variant associations with latent traits underlying depression, bipolar disorder, and schizophrenia.

Translational psychiatry - 6 Feb 2023

Dattani Saloni, Sham Pak C, Jermy Bradley S, Coleman Jonathan R I, Howard David M, Lewis Cathryn M

Abstract excerpt

Genetic studies in psychiatry have primarily focused on the effects of common genetic variants, but few have investigated the role of rare genetic variants, particularly for major depression. In order to explore the role of rare variants in the gap between estimates of single nucleotide polymorphism (SNP) heritability and twin study heritability, we examined the contribution of common and rare genetic variants to...

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Identifiers

PMID: 36746926
DOI: 10.1038/s41398-023-02324-6
PMCID: PMC9902570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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