Article
Identification of tumor mutations in plasma based on mutation variant frequency change (MVFC).
Molecular oncology - 1 Sept 2023
Chen Geng, Peng Fang, Dong Xiuqing, Cai Zhixiong, Li Zhenli, He Lei, Hu Jinpan, Deng Xiaoxu, Guo Yutong, Qiu Liman, Zhou Yang, Liu Jingfeng, Zhang Huqin, Liu Xiaolong
Abstract excerpt
To overcome the dependency of strategies utilizing cell-free DNA (cfDNA) on tissue sampling, the emergence of sequencing panels for non-invasive mutation screening was promoted. However, cfDNA sequencing with panels still suffers from either inaccuracy or omission, and novel approaches for accurately screening tumor mutations solely based on plasma without gene panel restriction are urgently needed. We performed...
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