Article
Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing.
Oncotarget - 28 Jun 2016
Liao Wenjun, Yang Huayu, Xu Haifeng, Wang Yanan, Ge Penglei, Ren Jinjun, Xu Wei, Lu Xin, Sang Xinting, Zhong Shouxian, Zhang Hongbing, Mao Yilei
Abstract excerpt
BACKGROUND: Detection of circulating cell-free DNA (cfDNA) has potential clinical value for assessing tumor biology in patients with hepatocellular carcinoma (HCC), yet many traditional assays lack robustness. This study was the first to apply a high-throughput sequencing platform to detect tumor-associated mutations in HCC from circulating tumor-derived DNA (ctDNA) and to evaluate the utility and feasibility of...
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