Article
A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma.
Oncogene - 1 Jul 2018
Labgaa Ismail, Villacorta-Martin Carlos, D'Avola Delia, Craig Amanda J, von Felden Johann, Martins-Filho Sebastiao N, Sia Daniela, Stueck Ashley, Ward Stephen C, Fiel M Isabel, Mahajan Milind, Tabrizian Parissa, Thung Swan N, Ang Celina, Friedman Scott L, Llovet Josep M, Schwartz Myron, Villanueva Augusto
Abstract excerpt
Cellular components of solid tumors including DNA are released into the bloodstream, but data on circulating-free DNA (cfDNA) in hepatocellular carcinoma (HCC) are still scarce. This study aimed at analyzing mutations in cfDNA and their correlation with tissue mutations in patients with HCC. We included 8 HCC patients treated with surgical resection for whom we collected paired tissue and plasma/serum samples. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.