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Article

Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel.

PloS one - 1 Jan 2016

Sato Kei A, Hachiya Tsuyoshi, Iwaya Takeshi, Kume Kohei, Matsuo Teppei, Kawasaki Keisuke, Abiko Yukito, Akasaka Risaburo, Matsumoto Takayuki, Otsuka Koki, Nishizuka Satoshi S

Abstract excerpt

BACKGROUND: Circulating tumor DNA (ctDNA) carries information on tumor burden. However, the mutation spectrum is different among tumors. This study was designed to examine the utility of ctDNA for monitoring tumor burden based on an individual mutation profile. METHODOLOGY: DNA was extracted from a total of 176 samples, including pre- and post-operational plasma, primary tumors, and peripheral blood mononuclear...

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Genes, Neoplasm

Share to Leukocytes, Mononuclear

Share to Multiplex Polymerase Chain Reaction

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Identifiers

PMID: 26727500
DOI: 10.1371/journal.pone.0146275
PMCID: PMC4699643

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