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Article

The chemokine receptor CCR5-Delta32 gene mutation is not protective against Alzheimer's disease.

Neuroscience letters - 19 Aug 2004

Combarros Onofre, Infante Jon, Llorca Javier, Peña Nicolás, Fernández-Viadero Carlos, Berciano José

Abstract excerpt

Chronic local inflammatory reaction involving reactive microglia is one of the major pathological events in Alzheimer's disease (AD). There is growing evidence that the chemokine receptor CCR5 is up-regulated in AD brain and plays a role in the recruitment and accumulation of microglia in senile plaques. A 32-base pair deletion in the CCR5 gene (CCR5-Delta32 mutant allele) confers resistance to HIV-1 infection by...

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Source

Identifiers

PMID: 15288441
DOI: 10.1016/j.neulet.2004.05.058

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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