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Azacytidine causes complex DNA methylation responses in myeloid leukemia

1 Sept 2008

Abstract excerpt

Aberrant DNA methylation patterns play an important role in the pathogenesis of hematologic malignancies. The DNA methyltransferase inhibitors azacytidine and decitabine have shown significant clinical benefits in the treatment of myelodysplastic syndrome (MDS), but their precise mode of action remains to be established. Both drugs have been shown the ability to deplete DNA methyltransferase enzymes and to induce...

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PMID: 18790780
DOI: 10.1158/1535-7163.mct-08-0411

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