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Elucidating the Proximal Tubule HNF4A Gene Regulatory Network in Human Kidney Organoids

25 Jul 2023

Abstract excerpt

SIGNIFICANCE STATEMENT: HNF4 genes promote proximal tubule differentiation in mice, but their function in human nephrogenesis is not fully defined. This study uses human pluripotent stem cell (PSC)-derived kidney organoids as a model to investigate HNF4A and HNF4G functions. The loss of HNF4A , but not HNF4G , impaired reabsorption-related molecule expression and microvilli formation in human proximal tubules....

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Ion Transport and Channel Regulation
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PMID: 37488681
DOI: 10.1681/asn.0000000000000197

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