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Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank.

Journal of affective disorders - 15 Oct 2023

Forsyth Lewis, Aman Alisha, Cullen Breda, Graham Nicholas, Lyall Donald M, Lyall Laura M, Pell Jill P, Ward Joey, Smith Daniel J, Strawbridge Rona J

Abstract excerpt

BACKGROUND: People with severe mental illness have a higher risk of cardiometabolic disease than the general population. Traditionally attributed to sociodemographic, behavioural factors and medication effects, recent genetic studies have provided evidence of shared biological mechanisms underlying mental illness and cardiometabolic disease. We aimed to determine whether signals in the DCC locus, implicated in...

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PMID: 37487843
DOI: 10.1016/j.jad.2023.07.052

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