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Article

Genetic variation in circadian regulator gene BMAL1 in psychiatric, psychological and cardiometabolic traits: a trans-ancestry UK Biobank study.

BMJ mental health - 12 Dec 2024

Daudali Hamza, Anderson Jana, Bailey Mark E S, Fradera Alexander, Niedzwiedz Claire L, Lyall Donald, Lyall Laura M M, Strawbridge Rona J

Abstract excerpt

BACKGROUND: The link between cardiometabolic disease and mental illness has been well established but remains incompletely explained. One hypothesis suggests that circadian rhythm dysregulation links cardiometabolic disease and mental illnesses. BMAL1 is a circadian rhythm regulatory gene. Human genetic studies have implicated BMAL1 in depression, schizophrenia, bipolar disorder as well as body mass index, blood...

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Identifiers

PMID: 39667926
DOI: 10.1136/bmjment-2024-301267
PMCID: PMC11647332

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BMAL1

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