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Blockade of the mineralocorticoid receptor improves markers of human endothelial cell dysfunction and hematological indices in a mouse model of sickle cell disease

21 Jul 2023

Abstract excerpt

Abstract Increased endothelin‐1 (ET‐1) levels in patients with sickle cell disease (SCD) and transgenic mouse models of SCD contribute to disordered hematological, vascular, and inflammatory responses. Mineralocorticoid receptor (MR) activation by aldosterone, a critical component of the Renin‐Angiotensin‐Aldosterone‐System, modulates inflammation and vascular reactivity, partly through increased ET‐1 expression....

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PMID: 37482902
DOI: 10.1096/fj.202300671r

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