Article

Beclin-1 restrains aldosterone signaling via autophagic degradation of the mineralocorticoid receptor to protect against cardiovascular injury

2026-05-21

Abstract excerpt

Cells deploy adaptive programs to maintain homeostasis under stress, yet mechanisms counteracting damage triggered by transmembrane signaling remain poorly defined. Using a hyperaldosteronism model, we examined how autophagy regulates aldosterone-mediated mineralocorticoid receptor (MR) activation. In human umbilical vein endothelial cells (HUVECs), aldosterone induced autophagy, as evidenced by elevated Beclin-1,...

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Literature Corpus work: 8d0fba10-a3d4-53e6-800f-ffc1b5956b1c
DOI: 10.64898/2026.05.19.726128

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