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Article

A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade.

American journal of hematology - 1 Nov 2017

Solovey Anna, Somani Arif, Belcher John D, Milbauer Liming, Vincent Lucile, Pawlinski Rafal, Nath Karl A, Kelm Robert J, Mackman Nigel, O'Sullivan M Gerard, Gupta Kalpna, Vercellotti Gregory M, Hebbel Robert P

Abstract excerpt

Elaboration of tumor necrosis factor (TNF) is a very early event in development of ischemia/reperfusion injury pathophysiology. Therefore, TNF may be a prominent mediator of endothelial cell and vascular wall dysfunction in sickle cell anemia, a hypothesis we addressed using NY1DD, S+SAntilles , and SS-BERK sickle transgenic mice. Transfusion experiments revealed participation of abnormally activated blood...

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Identifiers

PMID: 28699284
DOI: 10.1002/ajh.24856
PMCID: PMC5655742

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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