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Article

Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding.

PloS one - 1 Jan 2020

Chitongo Rumbidzai, Obasa Adetayo Emmanuel, Mikasi Sello Given, Jacobs Graeme Brendon, Cloete Ruben

Abstract excerpt

Resistance associated mutations (RAMs) threaten the long-term success of combination antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand transfer inhibitors (INSTIs) have proven to be a viable option for highly specific HIV-1 therapy. The INSTI, Dolutegravir is recommended by the World Health Organization for use as first-line cART. This study aims to understand how RAMs affect...

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Identifiers

PMID: 32379830
DOI: 10.1371/journal.pone.0223464
PMCID: PMC7205217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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