Article
HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants.
Antimicrobial agents and chemotherapy - 1 Sept 2018
Smith Steven J, Zhao Xue Zhi, Burke Terrence R, Hughes Stephen H
Abstract excerpt
Integrase strand transfer inhibitors (INSTIs) have emerged as clinically effective therapeutics that inhibit HIV-1 replication by blocking the strand transfer reaction catalyzed by HIV-1 integrase (IN). Of the three FDA-approved INSTIs, dolutegravir (DTG) is the least apt to select for resistance. However, recent salvage therapy regimens had low response rates with therapies that included DTG, suggesting that DTG...
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