Article
Genetic requirements for PIE-1 localization and inhibition of gene expression in the embryonic germ lineage of Caenorhabditis elegans.
Developmental biology - 15 Aug 1998
Tenenhaus C, Schubert C, Seydoux G
Abstract excerpt
In early Caenorhabditis elegans embryos, production of new mRNAs is inhibited in the germ lineage. This inhibition requires the germline factor PIE-1, and correlates with the absence in germline blastomeres of a phosphoepitope on RNA polymerase II (RNAPII-H5). We show that PIE-1 is uniformly dist...
Topics
- Animals
- Antibodies, Monoclonal
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cytoplasmic Granules
- DNA
- Fluorescent Antibody Technique
- Gene Expression Regulation, Developmental
- Germ Cells
- Heterozygote
- In Situ Hybridization
- Mutation
- Nuclear Proteins
- Oocytes
- Phenotype
- RNA Polymerase II
- RNA, Messenger
- Transcriptional Activation