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Programmed DNA Breaks Activate the Germline Genome in Caenorhabditis elegans.

Developmental cell - 6 Aug 2018

Wong Matthew M, Belew Mezmur D, Kwieraga Amanda, Nhan James D, Michael W Matthew

Abstract excerpt

In Caenorhabditis elegans, the primordial germ cells Z2 and Z3 are born during early embryogenesis and then held in a transcriptionally quiescent state where the genome is highly compacted. When hatched L1s feed, the germline genome decompacts, and RNAPII is abruptly and globally activated. A previously documented yet unexplained feature of germline genome activation in the worm is the appearance of numerous DNA...

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PMID: 30086301
DOI: 10.1016/j.devcel.2018.07.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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