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Article

Genetically engineered mouse models of PI3K signaling in breast cancer

11 Feb 2013

Abstract excerpt

Breast cancer is the most common type of cancer in women. A substantial fraction of breast cancers have acquired mutations that lead to activation of the phosphoinositide 3-kinase (PI3K) signaling pathway, which plays a central role in cellular processes that are essential in cancer, such as cell survival, growth, division and motility. Oncogenic mutations in the PI3K pathway generally involve either activating...

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PMID: 23478237
DOI: 10.1016/j.molonc.2013.02.003

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