Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated PI3K signaling drives multiple Breast Cancer subtypes

5 Jun 2011

Abstract excerpt

Jessica R. Adams 1,2 , Nathan F. Schachter 1,2 , Jeff C. Liu 3 , Eldad Zacksenhaus 3,4 and Sean E. Egan 1,2 1 Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St., East Tower 2 The Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada 3 Division of Cell and Molecular Biology, Toronto General Research Institute–University Health Network,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to FOXO transcription factor regulation
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21646685
DOI: 10.18632/oncotarget.285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated PI3K signaling drives multiple Breast Cancer subtypesPMID 21646685Read ↗

Genetically engineered mouse models of PI3K signaling in breast cancerSemantic proximity Read ↗

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms.Semantic proximity Read ↗

The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancerSemantic proximity Read ↗

PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data.Semantic proximity Read ↗

Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors.Semantic proximity Read ↗

Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer.Semantic proximity Read ↗

Targeting PI3K/AKT/mTOR Pathway in Breast Cancer: From Biology to Clinical ChallengesSemantic proximity Read ↗

Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations.Semantic proximity Read ↗

Biology and therapeutic potential of PI3K signaling in ER+/HER2-negative breast cancer.Semantic proximity Read ↗

Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer.Semantic proximity Read ↗

Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapiesSemantic proximity Read ↗

Overview of the relevance of PI3K pathway in HR-positive breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.