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Article

Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis

29 Sept 2023

Abstract excerpt

Inclusion body myositis (IBM) is unique across the spectrum of idiopathic inflammatory myopathies (IIM) due to its distinct clinical presentation and refractoriness to current treatment approaches. One explanation for this resistance may be the engagement of cell-autonomous mechanisms that sustain or promote disease progression of IBM independent of inflammatory activity. In this study, we focused on senescence...

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Share to Inflammatory Myopathies and Dermatomyositis
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PMID: 37773216
DOI: 10.1007/s00401-023-02637-2

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