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Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer

18 Jul 2023

Abstract excerpt

Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship in treatment-naive animals, we hereby describe mammary-specific transposon-mutagenesis screens in female mice together with loss-of-function Rb, which is frequently inactivated in breast-cancer. We...

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PMID: 37463901
DOI: 10.1038/s41467-023-39935-y

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