HLA and KIR Associations of Cervical Neoplasia.

doi:10.1093/infdis/jiy483

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Article

HLA and KIR Associations of Cervical Neoplasia.

The Journal of infectious diseases - 5 Nov 2018

Bao Xiao, Hanson Aimee L, Madeleine Margaret M, Wang Sophia S, Schwartz Stephen M, Newell Felicity, Pettersson-Kymmer Ulrika, Hemminki Kari, Tiews Sven, Steinberg Winfried, Rader Janet S, Castro Felipe, Safaeian Mahboobeh, Franco Eduardo L, Coutlée François, Ohlsson Claes, Cortes Adrian, Marshall Mhairi, Mukhopadhyay Pamela, Cremin Katie, Johnson Lisa G, Garland Suzanne M, Tabrizi Sepehr N, Wentzensen Nicolas, Sitas Freddy, Trimble Cornelia, Little Julian, Cruickshank Maggie, Frazer Ian H, Hildesheim Allan, Brown Matthew A, Duncan Emma L, Sun Ying Pu, Leo Paul J

Abstract excerpt

Background: Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognized by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inheritance of...

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Identifiers

PMID: 30099516
DOI: 10.1093/infdis/jiy483
PMCID: PMC6217726

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