Article
Association of the genetic diversity of killer cell immunoglobulin-like receptor genes and HLA-C ligand in Saudi women with breast cancer.
Immunogenetics - 1 Feb 2017
Alomar Suliman Y, Alkhuriji Afrah, Trayhyrn Paul, Alhetheel Abdulkarim, Al-Jurayyan Abdullah, Mansour Lamjed
Abstract excerpt
Breast cancer (BC) progression and metastases have been linked to antitumor immunity inefficiency and particularly to natural killer (NK) cells. Killer cell immunoglobulin-like receptors (KIRs) are the most polymorphic receptors of NK cells. Through their interactions with human leukocyte antigen (HLA)-C ligands, they modulate NK and T cell actions against target cells. Therefore, we studied the combinatorial...
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