Article
Analysis of KIR gene frequencies and HLA class I genotypes in breast cancer and control group.
Human immunology - 1 Sept 2013
Jobim Maria Regina, Jobim Mariana, Salim Patrícia H, Portela Pâmela, Jobim Luiz Fernando, Leistner-Segal Sandra, Bittelbrunn Ana Cristina, Menke Carlos Henrique, Biazús Jorge Villanova, Roesler Rafael, Schwartsmann Gilberto
Abstract excerpt
Breast cancer is the main cause of cancer-related death among women, with a 0.5% increase in incidence per year. Natural killer cells (NK) are part of the innate immune system recognizing class I HLA molecules on target cells through their membrane receptors, called killer cell immunoglobulin-like receptors (KIR). The aim of our study was to evaluate the association between the KIR genes and HLA alleles in...
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