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Article

Identification of the Hub Gene LDB3 in Stanford Type A Aortic Dissection Based on Comprehensive Bioinformatics Analysis.

Journal of cellular and molecular medicine - 1 Mar 2025

Liu Xinyi, Liu Xing, Wan Bin, Ge Yipeng, Hu Haiou, Yu Hong, Zhao Meng, Li Huadong, Zhu Junming

Abstract excerpt

Stanford type A aortic dissection (TAAD) is a life-threatening disease. This study explored the role of LIM domain binding 3 (LDB3) in TAAD progression. Four datasets from the Gene Expression Omnibus were analyzed to identify TAAD-related hub genes. LDB3 single nucleotide polymorphisms (SNPs) were assessed in the UK Biobank. Western blotting and immunofluorescence detected LDB3 expression in angiotensin II (Ang...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 40099963
DOI: 10.1111/jcmm.70471
PMCID: PMC11916769

Genes

LDB3
TIMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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