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Genome-wide CRISPR screening identifies PHF8 as an effective therapeutic target for KRAS- or BRAF-mutant colorectal cancers

25 Feb 2025

Abstract excerpt

BACKGROUND: Mutations in KRAS and BRAF genes are prevalent in colorectal cancer (CRC), which strikingly promote tumorigenesis and lead to poor response to a variety of treatments including immunotherapy by activating the MAPK/ERK pathway. Thus, there is an urgent need to discover effective therapeutic targets and strategies. METHODS: CRISPR-Cas9 lentiviral knockout library was used to screen the suppressors of...

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PMID: 40001243
DOI: 10.1186/s13046-025-03338-2

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