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miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia

15 Jul 2023

Abstract excerpt

Acute myeloid leukemia (AML) is a hematological malignancy characterized by the impaired differentiation and uncontrolled proliferation of myeloid blasts. Tumor suppressor p53 is often downregulated in AML cells via ubiquitination-mediated degradation. While the role of E3 ligase MDM2 in p53 ubiquitination is well-accepted, little is known about the involvement of deubiquitinases (DUBs). Herein, we found that the...

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PMID: 37454155
DOI: 10.1038/s41420-023-01537-4

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