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Article

Yin Yang 1 is a negative regulator of p53.

Cell - 25 Jun 2004

Sui Guangchao, Affar El Bachir, Shi Yujiang, Brignone Chrystelle, Wall Nathan R, Yin Peng, Donohoe Mary, Luke Margaret P, Calvo Dominica, Grossman Steven R, Shi Yang

Abstract excerpt

Yin Yang 1 (YY1) is a transcription factor that plays an essential role in development. However, the full spectrum of YY1's functions and mechanism of action remains unclear. We find that YY1 ablation results in p53 accumulation due to a reduction of p53 ubiquitination in vivo. Conversely, YY1 overexpression stimulates p53 ubiquitination and degradation. Significantly, recombinant YY1 is sufficient to induce...

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Identifiers

PMID: 15210108
DOI: 10.1016/j.cell.2004.06.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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