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Article

NPM1 mutant maintains ULK1 protein stability via TRAF6-dependent ubiquitination to promote autophagic cell survival in leukemia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021

Tang Yuting, Tao Yao, Wang Lu, Yang Liyuan, Jing Yipei, Jiang Xueke, Lei Li, Yang Zailin, Wang Xin, Peng Meixi, Xiao Qiaoling, Ren Jun, Zhang Ling

Abstract excerpt

Nucleophosmin (NPM1) mutations are the most frequent genetic alteration in acute myeloid leukemia (AML) and aberrant cytoplasm-dislocated NPM1 mutant is a distinct biological characterization of this disease. Our group previously reported that NPM1 mutant elevated autophagy activity and autophagy activation contributed to leukemic cell survival. However, the molecular mechanisms by which cytoplasmic NPM1 mutant...

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PMID: 33201521
DOI: 10.1096/fj.201903183RRR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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