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Article

Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms.

Cells - 24 Jun 2023

Bovari-Biri Judit, Abdelwahab ElHusseiny Mohamed Mahmoud, Garai Kitti, Pongracz Judit E

Abstract excerpt

(1) Background: Tuberous sclerosis complex (TSC) mutations directly affect mTORC activity and, as a result, protein synthesis. In several cancer types, TSC mutation is part of the driver mutation panel. TSC mutations have been associated with mitochondrial dysfunction, tolerance to reactive oxygen species due to increased thioredoxin reductase (TrxR) enzyme activity, tolerance to endoplasmic reticulum (ER)...

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Identifiers

PMID: 37443747
DOI: 10.3390/cells12131713
PMCID: PMC10340296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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