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Article

Growth Control Under Stress: mTOR Regulation through the REDD1-TSC Pathway

22 Aug 2005

Abstract excerpt

Dysregulated signaling by the checkpoint kinase TOR (target of rapamycin) has been linked to numerous human cancers. The tuberous sclerosis tumor suppressors TSC1 and TSC2 form a protein complex that integrates and transmits cellular growth factor and stress signals to negatively regulate TOR activity. Several recent reports have identified the stress response gene REDD1 as an essential regulator of TOR activity...

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PMID: 16258273
DOI: 10.4161/cc.4.11.2139

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