Article
Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited.
Apoptosis : an international journal on programmed cell death - 1 Jun 2021
Abdelwahab ElHusseiny M M, Bovari-Biri Judit, Smuk Gabor, Fillinger Janos, McPhail Donald, Krymskaya Vera P, Pongracz Judit E
Abstract excerpt
Tuberous sclerosis, angiomyolipoma and lymphangioleiomyomatosis are a group of diseases characterized by mutation in tuberous sclerosis genes (TSC 1-2). TSC mutation leads to continuous activation of the mTOR pathway that requires adaptation to increased ATP requirement. With limited treatment options, there is an increasing demand to identify novel therapeutic targets and to understand the correlations between...
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