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Article

Heterogeneous components of lung adenocarcinomas confer distinct EGFR mutation and PD-L1 expression.

BMC cancer - 24 Feb 2020

Cai Yiran, Wu Hongbo, Shi Xiaoqin, Dong Yujie, Chang Xiujun, Zhang Li, Zhou Lijuan, Su Dan, Yang Ming

Abstract excerpt

BACKGROUND: Lung adenocarcinoma (LAC) is composed of lepidic, papillary, mucinous, micropapillary and solid components in its parenchyma. Complex responses to therapeutics result from intratumoral heterogeneity. However, it remains confused that what components in a mixed LAC tumor are responsible to the heterogeneous EGFR mutation and PD-L1 expression. METHODS: We investigated EGFR status via laser...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32093629
DOI: 10.1186/s12885-020-6631-z
PMCID: PMC7041262

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