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Article

The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair.

Nucleic acids research - 5 Feb 2026

Kim Mihyun, Jeong Eunwoo, Park Jiyoung, D'Souza Areetha, Tsai Miaw-Sheue, Yan Chunli, Ivanov Ivaylo, Chazin Walter J, Kim Hyun Suk, Schärer Orlando D

Abstract excerpt

Nucleotide excision repair (NER) is the key pathway for the removal of DNA damage induced by UV irradiation and chemotherapeutic reagents. Protein-protein interactions are crucial for the dynamic and coordinated assembly of the proteins involved in DNA lesions. Here we focus on the role of interactions between the multi-subunit helicase/translocase complex TFIIH and the 3' endonuclease XPG. We show that XPG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41641700
DOI: 10.1093/nar/gkag078
PMCID: PMC12873601

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair.PMID 41641700Read ↗

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The role of Transcription Factor IIH complex in nucleotide excision repairSemantic proximity Read ↗

Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Semantic proximity Read ↗

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A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair.Semantic proximity Read ↗

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