Article
Environment-by-PGS Interaction in the Classical Twin Design: An Application to Childhood Anxiety and Negative Affect.
Multivariate behavioral research - 1 Jan 2000
Bruins Susanne, Hottenga Jouke-Jan, Neale Michael C, Pool René, Boomsma Dorret I, Dolan Conor V
Abstract excerpt
One type of genotype-environment interaction occurs when genetic effects on a phenotype are moderated by an environment; or when environmental effects on a phenotype are moderated by genes. Here we outline these types of genotype-environment interaction models, and propose a test of genotype-environment interaction based on the classical twin design, which includes observed genetic variables (polygenic scores:...
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