A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders.

doi:10.1159/000444023

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Article

A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders.

Psychotherapy and psychosomatics - 1 Jan 2016

Keers Robert, Coleman Jonathan R I, Lester Kathryn J, Roberts Susanna, Breen Gerome, Thastum Mikael, Bögels Susan, Schneider Silvia, Heiervang Einar, Meiser-Stedman Richard, Nauta Maaike, Creswell Cathy, Thirlwall Kerstin, Rapee Ronald M, Hudson Jennifer L, Lewis Cathryn, Plomin Robert, Eley Thalia C

Abstract excerpt

BACKGROUND: The differential susceptibly hypothesis suggests that certain genetic variants moderate the effects of both negative and positive environments on mental health and may therefore be important predictors of response to psychological treatments. Nevertheless, the identification of such variants has so far been limited to preselected candidate genes. In this study we extended the differential...

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PMID: 27043157
DOI: 10.1159/000444023
PMCID: PMC5079103

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