Article
TP53 Variant in the Blood of a Patient with Gastric Cancer Undergoing Tumor Profiling Tests Diagnosed as Clonal Hematopoiesis.
The American journal of case reports - 14 Jun 2022
Kawai Miki, Iijima-Yamashita Yuka, Taguchi Iku, Kataoka Masato, Sanada Masashi, Murakami Yoshiko, Kitagawa Chiyoe, Hattori Hiroyoshi
Abstract excerpt
BACKGROUND Clonal hematopoiesis is the production of a specific single clonal type of cell in the blood and is often found in cancer genomic profiling tests. When the clone carries a pathogenic variant, it may be important to differentiate between somatic or germline origin. The variant in the blood that has a lower minor allele frequency could reflect heterozygous germline origin, somatic mosaicism, and clonal...
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