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Genome-Wide Association Study for the Genetic Determinants of Thiopurine Methyltransferase Protein Expression in Human Livers and Racial Differences.

Pharmaceutical research - 1 Nov 2023

Smith Logan S, Wang Xinwen, Shi Jian, He Bing, Zhu Hao-Jie

Abstract excerpt

INTRODUCTION: Polymorphisms in the Thiopurine S-Methyltransferase (TPMT) gene are associated with decreased TPMT activity, but little is known about their impact on TPMT protein expression in the liver. This project is to conduct a genome-wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with altered TPMT protein expression in human livers and to determine if demographics...

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PMID: 37430149
DOI: 10.1007/s11095-023-03558-1

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