Article
Thiopurine S-methyltransferase pharmacogenetics: functional characterization of a novel rapidly degraded variant allozyme.
Biochemical pharmacology - 1 Apr 2010
Feng Qiping, Vannaprasaht Suda, Peng Yi, Angsuthum Susothorn, Avihingsanon Yingyos, Yee Vivien C, Tassaneeyakul Wichittra, Weinshilboum Richard M
Abstract excerpt
A novel human thiopurine S-methyltransferase (TPMT) variant allele, (319 T>G, 107Tyr>Asp, *27), was identified in a Thai renal transplantation recipient with reduced erythrocyte TPMT activity. The TPMT*27 variant allozyme showed a striking decrease in both immunoreactive protein level and enzyme activity after transient expression in a mammalian cell line. We set out to explore the mechanism(s) responsible for...
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