Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin.

Current drug metabolism - 1 Jan 2023

Sridharan Kannan, D Thirumal Kumar, Manikandan Suchetha, Prasanna Gaurav, Guruswamy Lalitha, Al Banna Rashed, Doss C George Priya

Abstract excerpt

AIM: The study aimed to identify the key pharmacogenetic variable influencing the therapeutic outcomes of warfarin using machine learning algorithms and bioinformatics tools. BACKGROUND: Warfarin, a commonly used anticoagulant drug, is influenced by cytochrome P450 (CYP) enzymes, particularly CYP2C9. MLAs have been identified to have great potential in personalized therapy. OBJECTIVE: The purpose of the study was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Cytochrome P-450 CYP2C9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P450 Family 4

Share to Machine Learning

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 37409551
DOI: 10.2174/1389200224666230705124329

Genes

CYP2C9
CYP4F2
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin.PMID 37409551Read ↗

Molecular functionality of CYP2C9 polymorphisms and their influence on drug therapy.Semantic proximity Read ↗

Mechanistic insights into the effect of CYP2C9*2 and CYP2C9*3 variants on the 7-hydroxylation of warfarin.Semantic proximity Read ↗

Influence of CYP2C9, VKORC1, and CYP4F2 polymorphisms on the pharmacodynamic parameters of warfarin: a cross-sectional study.Semantic proximity Read ↗

Pharmacogenetic determinants of warfarin in the Indian population.Semantic proximity Read ↗

Evaluation of supervised machine learning algorithms in predicting the poor anticoagulation control and stable weekly doses of warfarin.Semantic proximity Read ↗

Pharmacogenomics of CYP2C9: Functional and Clinical ConsiderationsSemantic proximity Read ↗

Assessing the Performance of In silico Tools and Molecular Dynamics Simulations for Predicting Pharmacogenetic Variant Impact.Semantic proximity Read ↗

Cytochrome P450 2C19 gene polymorphisms (CYP2C19*2 and CYP2C19*3) in chronic myeloid leukemia patients: in vitro and in silico studies.Semantic proximity Read ↗

Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity.Semantic proximity Read ↗

CYP2C9, VKORC1, CYP4F2, ABCB1 and F5 variants: influence on quality of long-term anticoagulation.Semantic proximity Read ↗

Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol.Semantic proximity Read ↗

Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.