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Article

Altered circadian behavior and light sensing in mouse models of Alzheimer’s disease

20 Jun 2023

Abstract excerpt

Circadian symptoms have long been observed in Alzheimer's disease (AD) and often appear before cognitive symptoms, but the mechanisms underlying circadian alterations in AD are poorly understood. We studied circadian re-entrainment in AD model mice using a "jet lag" paradigm, observing their behavior on a running wheel after a 6 h advance in the light:dark cycle. Female 3xTg mice, which carry mutations producing...

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Identifiers

PMID: 37409006
DOI: 10.3389/fnagi.2023.1218193

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