Article
Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1.
Molecular oncology - 1 Dec 2023
Trsova Iva, Hrustincova Andrea, Krejcik Zdenek, Kundrat David, Holoubek Aleš, Staflova Karolina, Janstova Lucie, Vanikova Sarka, Szikszai Katarina, Klema Jiri, Rysavy Petr, Belickova Monika, Kaisrlikova Monika, Vesela Jitka, Cermak Jaroslav, Jonasova Anna, Dostal Jiri, Fric Jan, Musil Jan, Dostalova Merkerova Michaela
Abstract excerpt
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene are frequent in myelodysplastic neoplasms (MDS). Because the splicing process is involved in the production of circular RNAs (circRNAs), we investigated the impact of SF3B1 mutations on circRNA processing. Using RNA sequencing, we measured circRNA expression in CD34+ bone marrow MDS cells. We defined circRNAs deregulated in a heterogeneous group of MDS...
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