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Article

Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts.

Journal of hematology & oncology - 7 Dec 2014

Visconte Valeria, Tabarroki Ali, Zhang Li, Parker Yvonne, Hasrouni Edy, Mahfouz Reda, Isono Kyoichi, Koseki Haruhiko, Sekeres Mikkael A, Saunthararajah Yogen, Barnard John, Lindner Daniel, Rogers Heesun J, Tiu Ramon V

Abstract excerpt

BACKGROUND: The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS) highlights the importance of the RNA-splicing machinery in MDS. We previously reported the presence of bone marrow (BM) RS in Sf3b1 heterozygous (Sf3b1 (+/-)) mice which are rarely found in mouse models of MDS. Sf3b1 (+/-) mice were originally engineered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25481243
DOI: 10.1186/s13045-014-0089-x
PMCID: PMC4266210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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