Article
Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.
Leukemia - 1 May 2023
Wedge Eileen, Ahmadov Ulvi, Hansen Thomas B, Gao Zongliang, Tulstrup Morten, Côme Christophe, Nonavinkere Srivatsan Sridhar, Ahmed Tanzir, Jespersen Jakob S, Schlotmann Balthasar C, Schöllkopf Claudia, Raaschou-Jensen Klas, Ødum Niels, Kjems Jørgen, Bak Rasmus O, Walter Matthew J, Grønbæk Kirsten, Kristensen Lasse S
Abstract excerpt
Mutations in U2AF1 are relatively common in myelodysplastic neoplasms (MDS) and are associated with an inferior prognosis, but the molecular mechanisms underlying this are not fully elucidated. Circular RNAs (circRNAs) have been implicated in cancer, but it is unknown how mutations in splicing factors may impact on circRNA biogenesis. Here, we used RNA-sequencing to investigate the effects of U2AF1 mutations on...
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