Article
Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells.
Leukemia - 1 May 2015
Dolatshad H, Pellagatti A, Fernandez-Mercado M, Yip B H, Malcovati L, Attwood M, Przychodzen B, Sahgal N, Kanapin A A, Lockstone H, Scifo L, Vandenberghe P, Papaemmanuil E, Smith C W J, Campbell P J, Ogawa S, Maciejewski J P, Cazzola M, Savage K I, Boultwood J
Abstract excerpt
The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndrome (MDS), particularly in patients with refractory anemia with ring sideroblasts (RARS). We investigated the functional effects of SF3B1 disruption in myeloid cell lines: SF3B1 knockdown resulted in growth inhibition, cell cycle arrest and impaired erythroid differentiation and deregulation of many genes and pathways,...
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