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Article

Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations.

Oncotarget - 1 Mar 2016

Aslan Derya, Garde Christian, Nygaard Mette Katrine, Helbo Alexandra Søgaard, Dimopoulos Konstantinos, Hansen Jakob Werner, Severinsen Marianne Tang, Treppendahl Marianne Bach, Sjø Lene Dissing, Grønbæk Kirsten, Kristensen Lasse Sommer

Abstract excerpt

Spliceosome mutations are frequently observed in patients with myelodysplastic syndromes (MDS). However, it is largely unknown how these mutations contribute to the disease. MicroRNAs (miRNAs) are small noncoding RNAs, which have been implicated in most human cancers due to their role in post transcriptional gene regulation. The aim of this study was to analyze the impact of spliceosome mutations on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26848861
DOI: 10.18632/oncotarget.7127
PMCID: PMC4891095

Genes

SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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