Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes

23 May 2016

Abstract excerpt

The splicing factor SF3B1 is the most frequently mutated gene in myelodysplastic syndromes (MDS), and is strongly associated with the presence of ring sideroblasts (RS). We have performed a systematic analysis of cryptic splicing abnormalities from RNA sequencing data on hematopoietic stem cells (HSCs) of SF3B1-mutant MDS cases with RS. Aberrant splicing events in many downstream target genes were identified and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27211273
DOI: 10.1038/leu.2016.149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromesPMID 27211273Read ↗

Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.Semantic proximity Read ↗

Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells.Semantic proximity Read ↗

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis.Semantic proximity Read ↗

Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome.Semantic proximity Read ↗

SF3B1 mutations in myelodysplastic syndromes: A potential therapeutic target for modulating the entire disease processSemantic proximity Read ↗

Somatic Mutation of SF3B1, a Gene Encoding a Core Component of RNA Splicing Machinery, in Myelodysplasia with Ring SideroblastsSemantic proximity Read ↗

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.Semantic proximity Read ↗

Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome.Semantic proximity Read ↗

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical FeaturesSemantic proximity Read ↗

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.Semantic proximity Read ↗

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.Semantic proximity Read ↗

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.